منابع مشابه
High-dose fenretinide in oral leukoplakia.
We previously showed that low-dose fenretinide (200 mg/d) had limited activity in retinoid-resistant oral leukoplakia (34% response rate) possibly because serum drug levels were insufficient to induce retinoid receptor-independent apoptosis. Therefore, we designed the single-arm phase II trial reported here to investigate whether higher-dose fenretinide would improve leukoplakia response over t...
متن کاملFenretinide activity in retinoid-resistant oral leukoplakia.
PURPOSE To test the hypothesis that the retinamide N-(4-hydroxyphenyl)retinamide (fenretinide) would be clinically active potentially via receptor-independent apoptosis and receptor-dependent effects in natural retinoid-resistant oral leukoplakia patients--the first test of this hypothesis in any in vivo setting. EXPERIMENTAL DESIGN A phase II trial of fenretinide (200 mg/d for 3 months) in o...
متن کاملProliferative verrucous leukoplakia misdiagnosed as oral leukoplakia
Correct diagnosis of white lesions of the oral cavity is sometimes difficult, because some oral white lesions behave differently and tend to change their appearance with time. Clinicians often wrongly diagnose such lesions as oral leukoplakias and treat simply. Lesions recur and turn malignant. Proliferative verrucous leukoplakia (PVL) is a distinct form of oral leukoplakia characterized by a h...
متن کاملOral leukoplakia: Diagnosis and treatment
BACKGROUND AND AIM: Oral leukoplakia (OL) is a common premalignant lesion. The possible benefits of specific interventions in preventing a malignant transformation of OL are not well understood. This review assesses different invasive treatment techniques for OL and evaluate the optimal treatment possibilities.METHODS: A Medline (PubMed) search was conducted and heterogeneity between the studie...
متن کاملMetallothionein immunoexpression in oral leukoplakia.
OBJECTIVES to report the immunoexpression of metallothionein in oral leukoplakia and to correlate with histological grade and clinical localization. Leukoplakia is the most common potentially malignant lesion of the oral cavity. As the histological study of oral leukoplakia can not predict precisely the malignant transformation of this lesion, and metallothionein is a protein that has been asso...
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ژورنال
عنوان ژورنال: Cancer Prevention Research
سال: 2009
ISSN: 1940-6207,1940-6215
DOI: 10.1158/1940-6207.capr-08-0100